Autism Symptoms

You can observe some Autism symptoms in a person as young as two years old and sometimes even younger. Here are the main Autism symptoms that will allow you to identify or wonder if your a member of your family, a friend or anyone else might be affected by this disorder. The severity of these Autism symptoms may vary as each individual is unique. That is why it is evaluated on a spectrum.

Wednesday, December 19, 2007

Scientists Hoping To Reverse Autism Symptoms In Some Patients

Scientists could be on the verge of a new treatment for autism, if the results of animal research hold up in people. A study in mice suggests that several drugs, including one that is poised to enter trials in human patients as soon as next year, could improve brain function and reverse the symptoms of some autistic patients.
So far, the research indicates the drugs will only be effective for one form of autism that is caused by a mutation of a gene on the X chromosome, a condition known as fragile X syndrome. But the researchers think there's a possibility the medications could also work for other cases of autism where the cause is unknown.
“I really hope that we can go beyond fragile X and see significant improvement in children with other types of autism,” said Mark Bear, a neuroscientist at the Massachusetts Institute of Technology who led the mice research.

Autism disorders strike 1 out of every 150 children. Currently there is no cure for autism, a complex developmental disorder that impairs a person’s ability to communicate and relate with others and is associated with a range of unusual repetitive behaviors, such as obsessively arranging objects.
The exact cause of the disorder remains elusive but it has been linked to a variety of genes, including the fragile X mutation that can lead to both mental retardation and autism. Most patients with fragile X will show some autism symptoms and about 20 percent will meet the criteria to be considered autistic. The mutation is thought to lead to mental problems because it causes hyperactivity of a brain protein called metabotropic glutamate receptor 5 (mGluR5) that normally plays a role in learning and memory.
A team led by Bear wondered if reducing levels of mGluR5 protein could restore normal brain function. The researchers used a combination of genetic engineering and selective breeding to produce a line of mice that had both the fragile X mutation and toned down levels of the mGluR5 protein in their brain. The intent was to get an idea of what would happen when the protein was suppressed using a drug in human patients.
In a finding that the researchers described as “remarkable” in Thursday’s issue of the scientific journal Neuron, the mice — which should have had mental retardation and autism-like symptoms due to the fragile X mutation — instead showed near-normal brain function and memory.


Pill in the worksThat was exciting in and of itself, because it indicated that blocking the mGluR5 protein could lead to improvements in some forms of autism and mental retardation. But Bear said the even more provocative implication is that a compound that does just that already exists. A few years ago, he founded Seaside Therapeutics, a small pharmaceutical firm in Cambridge, Mass., that is developing a mGluR5-blocking drug called STX107. The agent, which would be taken as a pill, has passed all the safety studies required for beginning studies in people.
Autism drugs in the pipeline
Three drugs are being developed for treating Fragile X/autism by blocking a brain protein called metabotropic glutamate receptor 5:
Drug: STX107 Firm behind it: Seaside TherapeuticsStatus: Company anticipates trials in patients starting in 2008
Drug: LithiumFirm behind it: Rush UniversityStatus: Currently in clinical trial in patients
Drug: FenobamFirm behind it: FRAXA/NeuropharmStatus: Already studied in humans for anxiety; slated to enter trials in Fragile X patients in 2008
Randall Carpenter, Seaside's president and chief executive officer, said he's “cautiously optimistic,” about STX107's potential to reverse autism symptoms in people. “These are really exciting findings, but we really don't know how helpful it's going to be until we test it in humans,” he said.
Seaside now plans to meet with the Food and Drug Administration to request approval to begin clinical trials involving people with fragile X syndrome and autism. Carpenter anticipates starting the initial human studies sometime next year.
Outside researchers also were enthusiastic about the potential of the compound.“It seems very promising indeed,” said Matthew Belmonte, a neuroscientist at Cornell University's Department of Human Development. He said the study in mice suggests that drugs that suppress mGluR5 can restore brain function without causing any other ill effects. That bodes well for human trials, Belmonte said, but he noted that suppressing a gene in an animal study is not the same as using a drug in people so there could be unforeseen risks that may turn up. Not everyone is on board, however. Sophia Colamarino, a neurobiologist and vice president of research for the advocacy group Autism Speaks, which helped fund Bear's research, said the finding “give us hope” that this could be a viable strategy for treating autism, but she added that it's too early to tell whether STX107 will improve autistic behaviors in people. The drug could reduce mGluR5 levels, but autism is such a complex disease, this may not be enough to restore normal behavior in patients, Colamarino said.
Two other drugs in the worksIf the drug does fail, there still may be hope for patients and their families. The Fragile X Research Foundation (FRAXA), which co-funded STX107 research, is supporting investigations involving two other drugs that block the same protein.
Lithium, which is used for treating depression and bipolar disorder, is being investigated for its potential to treat autism and fragile X by researchers at Rush University in Chicago.
And another compound called fenobam — initially developed as an anti-anxiety medication in the 1970s and then abandoned — is being revitalized for fragile X by Neuropharm, a Surrey, UK-based pharmaceutical company. “We believe that drugs which block mGluR5 have enormous potential for the treatment of fragile X and related developmental disorders, including many cases of autism,” said Katie Clapp, president and executive director of FRAXA.

Friday, December 07, 2007

Fever May Briefly Aleviate Autism Symptoms

The behavior of children with autism may improve during a fever, according to a first-of-kind study, “Behaviors Associated With Fever in Children With Autism Spectrum Disorders,” published Nov. 30 in Pediatrics.
Researchers hypothesize that fever may restore nerve cell communications in regions of the autistic brain. The restoration may help children improve socialization skills during a fever.
The study was based on 30 autistic children between ages 2 and 18 who were observed during and after a fever of at least 100.4 degrees Fahrenheit. More than 80 percent of the children showed some improvement in behavior during a fever and 30 percent showed significant improvement, researchers said. Behavior changes included longer concentration span, increased amount of talking and improved eye contact.
The study was written by Craig J. Newschaffer, Ph.D., professor and chair of the Department of Epidemiology and Biostatistics at Drexel University, and Laura K. Curran, Ph.D., an epidemiology doctoral degree graduate who Newschaffer advised before he joined Drexel from Johns Hopkins University.
“Any leads that suggest new biologic mechanisms that could be acted on through treatment are welcomed,” Newschaffer said.
Study data suggest that behavior changes may not solely be the byproduct of sickness and, consequently, could be the byproduct of a biologic response to fever. More research, however, is needed to prove fever-specific effects, researchers say.
Autism can limit social interactions and disable verbal and nonverbal communication. About 1.5 million Americans have some form of autism, according to the Autism Society of America. The cause of autism is unknown.
The study was co-written by Stephen O. Crawford, M.H.S., predoctoral fellow at Johns Hopkins University; Michael V. Johnston, M.D., research scientist in the Kennedy Krieger Institute; Li-Ching Lee, Ph.D., assistant scientist at Johns Hopkins University; and Dr. Andrew W. Zimmerman, M.D., pediatric neurologist and research scientist at the Kennedy Krieger Institute